Sally N Adebamowo, Donna Spiegelman, Walter C Willett, Kathryn M Rexrode, Association ranging from intakes from magnesium, potassium, and you may calcium and you will risk of heart attack: dos cohorts of us people and you can up-to-date meta-analyses, The fresh new Western Log out of Clinical Nutrients, Volume 101, Point 6, , Pages 1269–1277,

Abstract

Background: Prospective studies for the relation regarding magnesium, potassium, and you can calcium intakes which have coronary attack risk are contradictory, and to all of our studies, the outcome out of a blended mineral eating plan get wasn’t looked at.

Objective: I checked out relationships anywhere between consumption off magnesium, potassium, and you can calcium and you can likelihood of experience stroke within the 86,149 feamales in the fresh Nurses’ Health Data (NHS) We and you may 94,715 feamales in the brand new NHS II.

Design: Within potential cohort research, we computed Hours off coronary arrest by quintiles off intake for each mineral as well as a combined diet score of all 3 nutrition by using multivariate Cox proportional threat habits. Simultaneously, i current meta-analyses towards the diet intakes of them nutritional elements and likelihood of coronary attack.

Results: During realize-right up (30 y regarding NHS We; twenty-two y regarding NHS II) a maximum of 3780 incident coronary attack times was in fact documented. Pooled multivariate RRs of total coronary arrest for women about large compared with a low quintiles have been 0.87 (95% CI: 0.78, 0.97) getting complete magnesium, 0.89 (95% CI: 0.80, 0.99) for total potassium, and 0.97 (95% CI: 0.87, step one.09) to possess full calcium intake. Pooled RRs for females throughout the highest in contrast to a decreased quintiles out of a mixed nutrient diet plan get was 0.72 (95% CI: 0.65, 0.81) to possess complete coronary arrest, 0.78 (95% CI: 0.66, 0.92) having ischemic heart attack, and you will 0.80 (95% CI: 0.61, step 1.04) getting hemorrhagic coronary arrest. In the up-to-date meta-analyses of the many possible studies yet, the newest combined RR off total heart attack are 0.87 (95% CI: 0.83, 0.92) to possess an one hundred-mg/d increase in magnesium intake, 0.91 (95% CI: 0.88, 0.94) having good a thousand-mg/d upsurge in potassium consumption, and 0.98 (95% CI: 0.94, 1.02) to have a three hundred-mg/d boost in calcium intake.

Conclusions: A blended nutrient diet score was inversely of this risk of stroke. High intakes of magnesium and you will potassium not calcium supplements were in addition to significantly on the less chance of coronary arrest in women.

Addition

Magnesium is a vital mineral and cofactor to have >three hundred enzymatic responses in the human body ( 1). Magnesium ‘s the 2nd really-numerous intracellular cation next to potassium ( 2). Calcium supplements is considered the most-numerous nutrient in your body. Eg magnesium and you may potassium, calcium is actually critically in cardiovascular features ( 3). Large weight-loss intakes of each and every ones nutrition was basically claimed to straight down risk of blood circulation pressure ( 4– 7), which is the principal modifiable stroke exposure basis. not, only a few possible training tested the family relations ranging from slimming down and you can extra intakes of these nutrition and risk of coronary attack in women, and you will show was indeed inconsistent. Potential education for the Europe showed magnesium consumption, but not intake regarding potassium or calcium, is significantly with the quicker danger of coronary arrest ( 7, 8). In the usa, consumption away from potassium and you may magnesium, but not from calcium, was basically for the shorter heart attack exposure when you look at the men ( 9), whereas calcium supplements and you can potassium intakes, not magnesium intake, was indeed for the quicker coronary attack risk in females ( 10). Plus, you to study showed no overall association ranging from these nutrients and threat of heart attack ( 11).

The few prospective observational training which were held didn’t include follow-up beyond fifteen y and had a somewhat small number of event stroke occurrences, as well as in very degree, the newest independent aftereffect of for each mineral intake off drugs and you may heart attack products wasn’t checked-out. In this article, we offer proof into the connection of each nutrient consumption away from dieting and supplements that have danger of total, ischemic, and you can hemorrhagic experience shots. In addition, i hypothesized that a mixed diet score of all 3 nutritional elements may be associated with the reduced stroke risk mainly because nutritional elements can be found together in the items, and you can consumption are firmly correlated. We treated these tries in the Us ladies who was Pansexual dating service in fact then followed prospectively regarding dos high cohorts the latest Nurses’ Wellness Research (NHS) 5 We and you may II.