One of several 58 studies included in the detailed study, 41 have been instance account, one to are a situation collection, thirteen had been retrospective cohort knowledge, several were potential cohort degree, and another was a cross-sectional cohort studies. The female NF1 clients having cancer of the breast originated 23 additional regions, towards most of him or her coming from the usa off The united states (38%), Uk (31%), and you will The japanese (12%). Characteristics of these instances are revealed in Table step 1.

Breast cancer stage at time of diagnosis was reported in 54 cases (27 cases of patients < 50 years of age and 27 cases of patients ?50 years of age)

Of the 286 cases identified, 181 reported the age of the patient. Mean age at breast cancer diagnosis was 49.3 years with a median age of 46 years and an interquartile range of 38.3 to 58.0 years. The majority of the patients were < 50 years of age with 53% < 50 years old, 28% between 35 and 44 years old and 15% < 35 years old. Age distribution of the incidence of breast cancer identified in these NF1 cases was evaluated based on their age at the time of diagnosis and revealed a peak age of diagnosis between the ages of 34 to 44 years. 2a).

Descriptive research from cancer of the breast instances reported. an excellent Many years shipping of the occurrence of cancer of the breast identified inside the 181 NF1 clients than the SEER database claimed cancer of the breast many years shipments away from experience circumstances. b Shipping out of cancer of the breast stage on lifetime of medical diagnosis regarding breast cancer identified inside the 54 NF1 customers. c Decades shipping of one’s frequency off breast cancer passing understood into the 76 NF1 clients as compared to SEER database advertised breast cancers decades distribution out of deaths

Which incidence out of cancer of the breast circumstances was compared to SEER database for stated cancer of the breast many years shipments out of experience cases, which showed an optimum period of prognosis involving the age of 55 so you can 64 ages in the standard people (Fig

The type of breast cancer was reported in 110 cases; invasive ductal carcinoma (IDC) was the most commonly reported breast cancer subtype (75.5%). The other 176 breast cancer cases were identified as breast carcinoma. When analyzing all the female NF1 patients with breast cancer, the majority presented with stage I or II disease. However, when separated by age, women < 50 years of age presented with more advanced disease compared to those ?50 years of age (56% vs. 22% stage III-IV, respectively, p = 0.005; Fig. 2b).

Follow-up information was provided in 76 of the reported cases. http://datingranking.net/nl/instabang-overzicht Mean follow-up time was 44.7 months with a range of 1.9 to 204 months. Nearly half of the reported patients were dead at the time of last follow-up. Mean age at breast cancer death was 45.7 years with a median age of 48.5 years and an interquartile range of 41.3–59.7 years. The majority of the patients were < 50 years of age at time of breast cancer death with 64% < 50 years old, 38% between 35 and 44 years old and 10% < 35 years old. This incidence of breast cancer deaths was compared to the SEER database for reported breast cancer age distribution of deaths, demonstrating a peak age of death between the ages of 55 to 64 years in the general population (Fig. 2c). The relative survival of the female NF1 patients with breast cancer identified in this study was compared to the general population using the SEER database controlling for age and year at diagnosis for each patient (Fig. 3). The median survival for this entire NF1 breast cancer cohort was 5 years compared to the reported median breast cancer survival of over 20 years in the general population using the SEER database. When separated by age, the median survival of the female NF1 patients with breast cancer identified in this study was 5.58 years in those < 50 years of age and over 15 years in those ?50 years of age.