Hyperhomocysteinaemia represents an independent risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. Psoriasis is a chronic inflammatory skin disease associated with increased atherothrombosis and cardiovascular risk profile. The aim of this study is to investigate homocysteine, folic acid and vitamin B12 levels in a cohort of psoriatic patients and its relationship with the severity of the disease. A retrospective observational study in 98 patients with chronic plaque psoriasis and 98 healthy controls was performed. Total plasma homocysteine level, folic acid, vitamin B₁₂ and PASI index were assessed in every patient. Patients with psoriasis had plasma homocysteine levels higher than controls (57% of cases and 25% of controls; p12 plasma levels were lower in psoriatic patients than in controls (p = NS), lower levels of vitamin B₁₂ were found in patients with hyperhomocysteinaemia compared to patients with a normal value of homocysteine (p = 0.0009). The severity of psoriasis assessed according to PASI (±) did not directly correlate either with higher levels of homocysteine or with vitamin B₁₂ and folic acid plasma levels. In conclusion, a significantly higher prevalence of hyperhomocysteinaemia was found in psoriatic patients compared to healthy controls. A significant correlation between hyperhomocysteinaemia and lower vitamin B₁₂ levels, but not folic acid, was evidenced. On the contrary, our data do not correlate the high level of homocysteine with higher PASI scores or psoriasis type, suggesting that homocysteine level can be considered an independent risk factor in psoriatic patients.

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N2 – Hyperhomocysteinaemia stands for an independent risk basis to have atherosclerotic heart problems, heart attack, peripheral arterial occlusive situation and venous thrombosis. Psoriasis try a chronic inflammatory skin disease from the enhanced atherothrombosis and you will aerobic risk character. The aim of this study will be to take a look at the homocysteine, folic acidic and you will nutritional B12 membership from inside the a cohort of psoriatic clients and its own relationship with the seriousness of the disease. A good retrospective observational analysis for the 98 people having persistent plaque psoriasis and you can 98 healthy control was did. Total plasma homocysteine height, folic acidic, vitamin B12 and you can PASI list was basically examined in virtually any patient. Patients with psoriasis got plasma homocysteine profile more than controls (57% of circumstances and you can twenty-five% from control; p12 plasma membership was indeed lower in psoriatic people compared to regulation (p = NS), low levels out-of supplement B12 was basically used in patients with hyperhomocysteinaemia compared to the clients which have a consistent value of homocysteine http://datingranking.net/uk-american-dating/ (p = 0.0009). The severity of psoriasis reviewed predicated on PASI (±) don’t yourself associate sometimes having higher amounts of homocysteine or which have vitamin B12 and you can folic acid plasma membership. To summarize, a considerably higher incidence off hyperhomocysteinaemia was used in psoriatic customers as compared to suit regulation. A life threatening relationship anywhere between hyperhomocysteinaemia and lower vitamin B12 profile, not folic acid, try evidenced. Quite the opposite, our very own analysis do not associate the fresh advanced level of homocysteine having large PASI results or psoriasis particular, indicating you to definitely homocysteine height is deemed another risk foundation when you look at the psoriatic patients.

Abdominal – Hyperhomocysteinaemia is short for an independent risk basis for atherosclerotic cardiovascular disease, coronary arrest, peripheral arterial occlusive condition and you may venous thrombosis. Psoriasis try a chronic inflammatory skin condition associated with the enhanced atherothrombosis and you can aerobic chance character. The aim of this research is to try to take a look at homocysteine, folic acid and you can vitamin B12 levels in the an effective cohort of psoriatic people and its particular experience of the seriousness of the condition. An excellent retrospective observational studies into the 98 patients which have persistent plaque psoriasis and 98 suit regulation are performed. Overall plasma homocysteine level, folic acidic, supplement B12 and you may PASI list was indeed examined in any diligent. Clients which have psoriasis had plasma homocysteine account more than control (57% from cases and you can 25% regarding controls; p12 plasma levels have been lower in psoriatic patients compared to control (p = NS), low levels out-of supplement B12 was included in people with hyperhomocysteinaemia as compared to customers that have a routine property value homocysteine (p = 0.0009). The severity of psoriasis analyzed centered on PASI (±) don’t really correlate sometimes having highest quantities of homocysteine otherwise having vitamin B12 and you will folic acid plasma membership. To conclude, a dramatically high frequency out-of hyperhomocysteinaemia was used in psoriatic patients compared to healthy control. A critical correlation between hyperhomocysteinaemia and lower vitamin B12 membership, but not folic acidic, are confirmed. On the contrary, our very own research don’t associate the brand new advanced level from homocysteine which have high PASI ratings otherwise psoriasis kind of, indicating you to homocysteine height can be regarded as a separate risk factor for the psoriatic clients.